The feeling of loneliness can settle in the body—right down to the biochemical level. New research now shows that loneliness leaves visible traces in the blood, offering insights into overall health.
The Biological Fingerprint of Loneliness
A new study reveals that loneliness doesn’t just affect the mind—it can be directly observed in the proteins found in blood, which regulate vital bodily functions.
More Than 40,000 Participants Provided Data
Researchers analyzed blood samples from over 40,000 Britons and compared them to data about participants’ social lives and feelings of loneliness.
The Difference Between Loneliness and Isolation
The study clearly distinguishes between actual social isolation—having little contact with others—and the subjective feeling of loneliness. Both leave measurable marks on the body.
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175 Proteins Respond to Social Isolation
In people with limited social contact, researchers found changes in 175 different proteins—molecules crucial to the body’s internal systems.
Loneliness Alters Fewer but Critical Proteins
Loneliness affected 26 specific proteins—fewer than isolation, but with significant roles in immune function and metabolism.
Inflammation and Immunity Linked to Loneliness
Many of the proteins influenced by loneliness are involved in immune responses and inflammation—offering a possible biological explanation for disease risk.
Proteins Linked to Serious Illness
Half of the affected proteins were already known to be associated with cardiovascular disease, type 2 diabetes, and stroke.
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9 Out of 10 Linked to Premature Death
An alarming 90 percent of the proteins tied to loneliness and isolation were also linked to a higher risk of dying early.
Can Loneliness Change the Body?
The research suggests that loneliness might actually alter protein production—not just the other way around. This redefines loneliness as a biological as well as emotional condition.
Potential for Early Warning
The findings raise the possibility that shifts in protein profiles could serve as early warning signs of disease in lonely individuals—before symptoms appear.
More Studies Are Needed
Researchers emphasize the need for additional studies to confirm these findings and understand how they can be applied in practice.
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The article is based on information from Videnskab.dk
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