A groundbreaking study from the University of California, Irvine, suggests that a simple combination of two widely available dietary components may help the brain defend itself against Alzheimer’s disease by boosting its natural ability to clear toxic proteins.
A powerful natural compound
Researchers identified a key role for EGCG, a strong antioxidant found in one of the most popular beverages worldwide, green tea.
This compound has long been praised for its health benefits, but in this study, it revealed a new potential impact on brain function.
The vitamin connection
Alongside EGCG, scientists tested nicotinamide, a form of vitamin B3 that occurs naturally in foods like fish, eggs, grains, and legumes.
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Already considered safe and widely used as a supplement, it now shows promise in protecting brain cells.
Tested on mouse brain cells
The experiment was carried out on cultured mouse neurons.
When EGCG and nicotinamide were combined, researchers observed a significant boost in cellular energy levels and an improvement in the brain cells’ ability to eliminate harmful protein buildups.
The brain’s natural cleaning system
Central to the study is autophagy, the process by which brain cells recycle damaged or dead material.
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When this system slows down with age, toxic proteins accumulate, a hallmark of Alzheimer’s disease.
The role of GTP energy
The study highlighted GTP, an energy molecule critical to brain cell activity.
The tested combination significantly increased GTP levels, which in turn enhanced the brain’s self-cleaning capacity.
Why aging brains struggle
Earlier studies have shown that aging brains and Alzheimer’s patients typically exhibit lower levels of GTP.
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This energy deficit reduces their ability to clear away toxic proteins, accelerating cognitive decline.
Reducing amyloid-beta buildup
One of the most promising outcomes was the reduction of amyloid-beta accumulation.
This protein is strongly associated with Alzheimer’s, as it clumps together into plaques that damage brain tissue.
Rejuvenating brain function
The researchers believe the combination could restore energy levels in the brain to those typically seen in younger, healthier individuals.
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This could help maintain resilience against age-related degeneration.
Supported by earlier studies
Previous research has linked one component to reduced risks of white matter lesions, considered early markers of dementia, while the other has been associated with protection against stroke damage and slower neurodegeneration.
Together, they present a compelling synergy.
Still early days
The scientists emphasize that their findings are based on cell cultures from mice, not human trials.
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More extensive clinical studies will be needed to determine whether the effects can be replicated in people, and at what dosage.
Accessible in everyday diet
The encouraging part is that both compounds are already present in common foods and available as safe supplements.
Incorporating items like fish, eggs, legumes, whole grains, and certain beverages into a balanced diet could provide a natural way to support brain health.
This article is based on information from Walla.co.il.