A breakthrough by Swedish scientists could revolutionize treatment for one of the most aggressive childhood cancers.
By turning cancer cells into healthy nerve cells, researchers are opening a new path in cancer therapy.
A new strategy against childhood cancer
Researchers have identified a novel treatment approach for neuroblastoma, one of the most aggressive and deadly cancers in young children.
The power lies in two enzyme inhibitors
By combining two specific inhibitors of antioxidant enzymes, scientists achieved transformative results in mouse models.
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Cancer cells become nerve cells
Instead of killing all cancer cells, the treatment encourages some to mature into healthy and functional neurons, disrupting tumor growth.
Hope for resistant cases
About half of the children treated with retinoic acid develop resistance. This new method could offer a lifeline where current therapies fail.
Targeting PRDX6 and GSTP1
These two antioxidant enzymes help cancer cells survive oxidative stress. Disabling them undermines the tumor’s defense system.
High enzyme levels linked to poor outcomes
Children with elevated PRDX6 and GSTP1 levels often have worse prognoses. This insight gives researchers a specific target for therapy.
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From lab tests to live models
The results have been confirmed both in cultured cells and live mouse models, indicating strong preclinical potential.
Reducing long-term side effects
Current treatments often leave survivors with lifelong cognitive issues. This new method might preserve brain function while combating cancer.
One drug already FDA-recognized
One of the inhibitors is already designated an "orphan drug" by the U.S. FDA for a different adult diagnosis, which could fast-track its clinical use.
Human trials are next
The treatment will now be tested in clinical trials to assess its safety and efficacy in children, offering hope for a future cure.
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This article is based on information from Eleconomista.es.
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