You’ve probably done it yourself, choosing the “sugar-free” option without hesitation. It feels like a small win for your health, especially when trying to cut calories or manage blood sugar. But new findings suggest that habit might not be as risk-free as many assume.
A growing concern
Erythritol, a common sweetener found in low-carb and diet products, has surged in popularity over the past decade. Its appeal lies in delivering sweetness without the usual downsides of sugar.
However, researchers from the University of Colorado Boulder have raised new concerns about its biological impact.
Their study, published in the Journal of Applied Physiology, indicates that erythritol may influence how blood vessels in the brain behave (University of Colorado Boulder, 2026).
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Inside the findings
In controlled lab experiments, scientists exposed human brain vessel cells to levels comparable to a single sugar-free drink. The results showed measurable changes in how these cells functioned.
The researchers observed that the cells became less effective at relaxing, while also showing signs of increased oxidative stress.
At the same time, their ability to help dissolve blood clots appeared weakened (Journal of Applied Physiology, 2026).
Previous large-scale observational research in the U.S. and Europe has also linked higher erythritol levels in the bloodstream with increased rates of heart attack and stroke, adding weight to these findings.
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What to take away
These results are based on laboratory data, not long-term human trials, so conclusions should be drawn carefully.
Still, the consistency across studies is prompting experts to call for closer scrutiny.
For now, checking labels and moderating intake of sugar substitutes may be a sensible step as more evidence emerges.
Sources: Science Daily
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