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Doctors warn about the interaction between omeprazole, ibuprofen and physical strain

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Doctors say common medicines like omeprazole and ibuprofen can put extra strain on the body when combined with dehydration and physical exertion.

For many people, treating everyday discomfort has become automatic. A capsule for heartburn in the morning, a painkiller before training, and life goes on.

Because these medicines are so common, they are often seen as harmless. Yet doctors say problems can arise when familiar drugs are used regularly, combined, or taken during physical stress.

Recent international health reporting has highlighted concerns around the widespread use of omeprazole and ibuprofen. '

Health authorities and medical specialists stress that the issue is rarely occasional use, but rather repeated patterns that develop quietly over time.

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What health authorities focus on

Guidance from the NHS centres mainly on omeprazole, which reduces stomach acid and is widely prescribed for reflux and indigestion.

Clinical recommendations note that long-term use can reduce the body’s ability to absorb magnesium, iron and vitamin B12.

Low levels of these nutrients have been linked to fatigue, bone problems and effects on nerve and heart function.

For this reason, the NHS advises that prolonged use should be monitored by a healthcare professional.

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Why doctors raise concerns about exercise

Cardiologists and sports medicine specialists focus more on ibuprofen and related NSAID painkillers during physical exertion.

Their warning is based on how the body responds to stress. Intense exercise and heat increase fluid loss, which naturally lowers blood flow to the kidneys.

NSAIDs block substances that normally help the kidneys maintain circulation in these conditions.

When dehydration and NSAID use occur together, kidney function can be temporarily impaired and strain on the cardiovascular system can increase.

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This biological interaction helps explain why problems are more likely during endurance training, heavy workouts or prolonged activity, particularly when painkillers are taken preventively rather than for acute pain.

Other medicines to consider

Doctors also point out that additional drugs can influence the body under physical strain:

  • nasal decongestants that raise heart rate and blood pressure
  • some antidepressants that affect heart rhythm
  • certain blood pressure medications that alter mineral balance

The overall message from experts is one of awareness, not alarm. Medicines remain effective and safe when used correctly, but hydration, timing and medical guidance matter more than many people realise.

Sources: LADbible

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