A routine check-up can sometimes end with the same frustrating message: your blood pressure is still too high.
For many, even a combination of medications isn’t enough, leaving doctors with limited options and patients with growing concern.
Researchers now believe a new treatment could change that, according to Science Daily
A new approach
Scientists from University College London have tested a drug called baxdrostat in patients whose blood pressure remains uncontrolled despite existing therapies.
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The study, published in the New England Journal of Medicine, involved nearly 800 participants across more than 200 clinics worldwide.
After 12 weeks, patients taking the drug saw their blood pressure fall by close to 10 mmHg compared to those given a placebo.
According to the researchers, this level of reduction can significantly lower the risk of heart attacks and strokes.
How it works
The treatment targets aldosterone, a hormone that regulates salt and fluid levels in the body.
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In some people, excess production of this hormone contributes to persistently high blood pressure.
By blocking aldosterone production, baxdrostat addresses an underlying cause rather than simply managing symptoms.
This may explain why it showed results in patients who had not responded to other medications.
Potential impact
Hypertension affects around 1.3 billion people globally, with many unable to reach recommended levels.
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Key findings include:
- Around 40% achieved healthier blood pressure
- Effects lasted up to 32 weeks
- No major safety concerns were reported
Researchers suggest the drug could benefit millions worldwide, particularly those with resistant hypertension.
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